Lipoprotein(a)

•  Genetically determined elevations in lipoprotein(a) (Lp(a)) play an important role in accelerating atherosclerosis resulting in premature heart attack and stroke.¹ High level of Lp(a)  appears to be the foremost  risk factor that underlies the extreme prematurity, severity that underlies the malignant heart disease among Asian Indians with and without diabetes. ^2-9 For extensive dissertation on Lipoprotein (a) see Lp (a) Chapter.

Sources

1. Enas EA, Chacko V, Senthilkumar A, Puthumana N, Mohan V. Elevated Lipoprotein(a)-A Genetic Risk Factor for Premature Vascular Disease in People With and Without Standard Risk Factors: A Review. Dis Mon. Jan 2006;52(1):5-50.

2. Enas EA. Why is there an epidemic of malignant CAD in young Indians? Asian J Clin Cardiol. 1998;1:43-59.

3. Enas EA. Lipoprotein(a) as a determinant of coronary heart disease in young women: a stronger risk factor than diabetes? Circulation. Jan 27 1998;97(3):293-295.

4. Enas EA. Coronary artery disease epidemic in Indians: a cause for alarm and call for action. J Indian Med Assoc. Nov 2000;98(11):694-695, 697-702.

5. Enas EA. Lipoprotein(a) is an important genetic risk factor for coronary artery disease in Asian Indians. Am  J  Cardiol. 2001;88:201-202.

6. Enas EA. Why Indians are more susceptible to Coronary artery disease: Role of specific risk factors In: Chatterjee SS, ed. Update in Cardiology Hyderabad: Cardiology Society of India; 2007.

7. Enas EA, Dhawan J, Petkar S. Coronary artery disease in Asian Indians: lessons learnt and the role of lipoprotein(a). Indian Heart J. Jan-Feb 1997;49(1):25-34.

8. Mohan V, Deepa R, Haranath SP, et al. Lipoprotein(a) is an independent risk factor for coronary artery disease in NIDDM patients in South India. Diabetes Care. Nov 1998;21(11):1819-1823.

9. Hoogeveen RC, Gambhir JK, Gambhir DS, et al. Evaluation of Lp[a] and other independent risk factors for CHD in Asian Indians and their USA counterparts. J Lipid Res. 2001;42(4):631-638.